Why Alzheimer's Drug Approval Delay? $3 Billion in DMD Gene Therapy; ADHD Prevalence

Early use of erenumab (Aimovig) showed sustained efficacy compared with oral migraine preventives in treatment-resistant episodic migraine. (JAMA Neurology)

Net sales for eteplirsen (Exondys 51), golodirsen (Vyondys 53), and casimersen (Amondys 45) -- three genetically targeted therapies for Duchenne muscular dystrophy that received accelerated approval but have not provided confirmatory evidence of efficacy -- totaled $3.1 billion from 2016 to 2022. (JAMA)

Common disinfectant and flame retardant chemicals impaired oligodendrocyte development in mice and in a human organoid model of prenatal cortical development. (Nature Neuroscience)

Early childhood concussion resulted in significantly elevated postconcussive symptoms, which persisted 3 months after injury in some children. (JAMA Network Open)

The U.S. Government Accountability Office looked at home testing tools to help diagnose Alzheimer's, Parkinson's, and other neurodegenerative diseases.

Experts weighed in as the newly approved AvertD genetic test for opioid addiction prepares to roll out. (Washington Post)

The Alzheimer's Disease Sequencing Project identified 17 variants significantly associated with Alzheimer's within five genomic regions. (Alzheimer's and Dementia)

The prevalence of ever being diagnosed with attention deficit-hyperactivity disorder (ADHD) was 11.3% in children ages 5-17 years during 2020-2022, the CDC said. (NCHS Data Brief)

The complement inhibitor ravulizumab (Ultomiris) earned another indication, this time for adults with anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder, AstraZeneca said.

Physical activity significantly reduced the number of mental and neurologic symptoms both in acute COVID-19 and post-COVID condition in young women. (Scientific Reports)

The prion disease kuru likely led to the migration of women in the Eastern Highlands of Papua New Guinea. (American Journal of Human Genetics)

• Judy George covers neurology and neuroscience news for MedPage Today, writing about brain aging, Alzheimer's, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinson's, ALS, concussion, CTE, sleep, pain, and more. Follow